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KMID : 0043320130360111291
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Archives of Pharmacal Research
2013 Volume.36 No. 11 p.1291 ~ p.1301
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Chemical constituents of the stems of Celastrus rugosus
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Chang Ruijie
Wang Chunhui
Zeng Qi
Guan Bin
Zhang Weidong
Jin Huizi
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Abstract
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Two new sesquiterpene pyridine alkaloids rugosusines A and B (1 and 2), and thirty-one known compounds were isolated from the stems of Celastrus rugosus. The structures of new compounds were elucidated by detailed spectroscopic analysis, including HR-ESI?MS and 2D NMR spectroscopic data. All the compounds were isolated from this plant for the first time. The cytotoxicities of these compounds were tested against SKOV3 and MGC-803 cell lines by CCK-8 method.
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KEYWORD
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Celastrus rugosus, Rugosusine A, Rugosusine B, Cytotoxicity
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